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  1. Endosomal sorting of the Alzheimer amyloid precursor protein (APP) plays a key role in the biogenesis of the amyloid-β (Aβ) peptide Genetic lesions underlying Alzheimer's disease (AD) can act by interfering with this physiological process Specifically, proteins involved in trafficking between ....
  2. Translate Separador See 6 authoritative translations of Separador in English with example sentences and audio pronunciations...
  3. Lipoprotein Receptor SorLA (LRP11) within a Retromer complex (see pathways in the inset) is available to switch APP from the non-amyloidogenic pathway containing plasma membrane α-secretase for non-amyloidogenic processing to release non-fibrillar products...
  4. happiness, in good order Romany word used by super-chav Jamie Oliver Kushtipen was once the English Romany word for 'happiness' from a Persian word meaning 'happiness'...
  5. An amino acid per se is classified in C07D while peptides (starting from dipeptides) are classified in C07K Subclass C07K is a function oriented entry for the compounds themselves and does not cover the application or use of the compounds under the subclass definition For classifying such ....
  6. SORCS3 is an orphan receptor of the VPS10P domain receptor family, a group of sorting and signaling receptors central to many pathways in control of neuronal viability and function SORCS3 is highly expressed in the CA1 region of the hippocampus, but the relevance of this receptor for hippocampal ....
  7. Born in Jerusalem to R Raphael Yitzchak Zerachya Azulai, a Jerusalem scholar and great-grandson of Kabbalist Rabbi Avraham Azulai, author of Chesed Le'Avraham From his early years, he was a disciple of leading Jerusalem scholars and kabbalists, including Rabbi ,...
  8. Domeniul(categoria) ALIMENTE si BAUTURI din Directorul Web LEXXAS de produse ,servicii si marci inregistrate romanesti ,ordonate alfabetic ,administrat de operator uman ,detaliat...
  9. Explore Ruthi Daugherty's board "Home Interiors" on Pinterest | See more ideas about Home ideas, Homes and Apartments...
  10. Expert Review of Endocrinology & Metabolism Volume 9, 2014 - Issue 1 Submit an article Journal homepage , hypothalamus and nucleus accumbens (NA) and represent a major pathway of appetite regulation Alhadeff AL, Rupprecht LE, Hayes MR , Activation and functional characterization of the mosaic receptor SorLA/LR11 J Biol...
  11. Background Generation of the amyloid β (Aβ) peptide of Alzheimer's disease (AD) is differentially regulated through the intracellular trafficking of the amyloid β precursor protein (APP) within the secretory and endocytic pathways...
  12. Steel Separator S4A Moisture Separators are used to improve the quality of steam or compressed air either within the dis-tribution system or on the supply inlet to equipment Removal of moisture is by a series of baffles on which the suspended water droplets impinge and fall out...
  13. Background Retinal detachment (RD) can lead to proliferative vitreoretinopathy (PVR), a leading cause of intractable vision loss PVR is associated with a cytokine storm involving common proinflammatory molecules like IL6, but little is known about the source and downstream signaling of IL6 and the consequences for the retina...
  14. Polypeptides representative of proteins expressed by a given cell type and isolated nucleic acids that encode the polypeptides are disclosed The compositions and method described can be used to define a cell type at a given developmental, metabolic, or disease stage by identifying and cataloging proteins expressed in the cell The compositions can also be used in the manufacture of ....
  15. Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, et al The major CD9 and CD81 molecular partner Identification and characterization of the complex...
  16. Sorla, utalizing the natural coverage, shot arrows with striking accuracy, leaving bandits scattered about the trail with arrows in their backs Yin Yuming is a talented digital artist based in Singapore currently working for Yiron Design...
  17. The use of M6PR-deficient cell lines to assess the requirement for M6PR in AP-1 recruitment has led to conflicting conclusions (Le Borgne and Hoflack, 1997; Zhu et al, 1999) One model proposes that activated ARF initiates the formation of a specific binding site for AP-1, which in turn binds clathrin to promote the maturation of the budding ....
  18. Carol Lippa's profile, publications, research topics, and co-authors...
  19. As the EE gradually matures into a late endosome (LE), the ligands dissociate from the MPRs ( van Weering et al, 2010 ) Cargo hydrolases are finally released into the interior of the lysosome through fusion of the multivesicular LE with the lysosomal boundary membrane...
  20. The bidirectional transport between the Golgi complex and the endocytic pathway has to be finely regulated in order to ensure the proper delivery of newly synthetized lysosomal enzymes and the return of sorting receptors from degradative compartments The high complexity of these routes has led to ....
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  22. We have previously reported the purification and cDNA cloning of sortilin, a new putative 95 kDa sorting receptor of human brain (Petersen et al, 1997)Sortilin is a typical type-1 membrane protein, consisting of a large luminal domain, a single transmembrane segment and a short C-terminal cytoplasmic tail...
  23. The Library of Congress >Chronicling America >The daily dispatch >February 18, 1862 >Image 3 Search America's historic newspaper pages from 1789-1925 or use the US Newspaper Directory to find information about American newspapers published between 1690-present...
  24. Introduction Alzheimer's disease (AD) is the most common form of neurodegenerative dementia in the aged AD is neuropathologically characterized by abnormal accumulations of extracellular amyloid plaques and intracellular neurofibrillary tangles throughout cortical and limbic brain regions...
  25. Abstract Sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present within the cytosolic domains of the proteins Most signals consist of short, linear sequences of amino acid residu Some signals are referred to as tyrosine-based sorting signals and conform to the NPXY or YXXØ consensus motifs Other signals known as dileucine-based signals fit [DE]XXXL[LI ....
  26. Background Metabolically-obese, normal-weight (MONW) individuals are not obese in terms of weight and height but have a number of obesity-related features (eg greater visceral adiposity, insulin resistance, and increased risk of cardiovascular disease)...
  27. Methods, Fluorophores, and Review Chem Phys Lipids 1992 Oct;62(3):269-80 Detection of protein mediated glycosphingolipid clustering by the use of resonance ,...
  28. Accumulation of amyloid ? (A?) peptides in the brain is the key pathogenic factor driving Alzheimer's disease (AD) Endocytic sorting of amyloid precursor protein (APP) mediated by the vacuolar protein sorting (Vps10) family of receptors plays a decisive role in controlling the outcome of APP proteolytic processing and A? generation...
  29. The sortilin-related receptor SORLA is an endocytic receptor that belongs to the vacuolar protein sorting 10 (VPS10) domain receptor family SORLA binds to the amyloid precursor protein ()It functions as an intracellular sorting receptor as APP is being trafficked between the secretory pathway, the cell surface, and, subsequently, endosom...
  30. sorla le separator Steel Separator S4A - Spirax Sarco Steel Separator S4A Moisture Separators are used to improve the quality of steam or compressed air either within the dis-tribution system or on the supply inlet to equipment...